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Advanced SenePlex+® Renewal Serum with Retinol by SeneGence

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Advanced SenePlex+® Renewal Serum with Retinol

The optional night serum in SeneGence’s regimen, with encapsulated nano retinol. Serum first, moisturizer on top.

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Core regimen (SenePlex+) · Skincare

Evening Moisturizer – Dry

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$80

Price on SeneGence, checked Sept 2026

Part of SeneGence’s Core regimen collection.

  • Made for dry skin
  • Key ingredients: Orchid stem cells, niacinamide, HA
  • Targets lines, dryness, texture, sagging

Size 1.66 fl oz · 47 mL

Details

Orchid stem cells, niacinamide, HA

What it addresses

Lines, dryness, texture, sagging

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The full review

Evening Moisturizer (Dry) review: my honest take

ReviewCompareRoutineIngredientsSetsTipsFAQs

Skin typeDry

Key ingredientOrchid stem cells

Size1.66 fl oz / 47 mL

Price$80

The Dry Evening Moisturizer is the last step of SeneGence’s night routine for dry skin. It’s part of the SenePlex+ lineup and targets the list that tends to show up by bedtime: fine lines, dryness, rough texture and sagging. It goes on after makeup removal, 3 in 1 Cleanser, Facial Resurfacer and any serums.

If you only splurge on one step for dry skin, make it the one that stays on all night.

The formula uses orchid stem cells, which SeneGence describes as helping improve the appearance of sagging skin, with niacinamide and hyaluronic acid. It’s a different formula from the Dry DayTime Moisturizer, not a thicker copy, so the two are meant to work as a pair. It suits dry skin that feels tight by evening and wants its moisture step to do more than moisturize.

At $80 for 1.66 fl oz, it’s $10 more than the DayTime version. The Dry SkinCare Regimen Set ($265) includes both moisturizers, the Dry cleanser and EyeCreme. If your skin is more sensitive than dry, the Microbiome Restorative Evening Moisturizer ($90) is made for sensitive to oily skin and focuses on the barrier.

Best for

Dry skin that wants night moisture with a focus on lines, texture and firmness.

Skip it if

You’re only a little dry. The Normal to Dry Evening Moisturizer is the better match.

Dry vs Normal to Dry vs Microbiome Restorative: which night moisturizer should you get?

Evening Moisturizer, Dry My pickEvening Moisturizer, Normal to DryMicrobiome Restorative Evening Moisturizer
Skin typeDryNormal to drySensitive to oily
Key ingredientsOrchid stem cells, niacinamide, HAOrchid stem cells, mushroom stem, rosehip, mangosteenLactobacillus ferments, HA, DS-CERIX5 lipids
TargetsLines, dryness, texture, saggingLines, firmness, tone, drynessLines, barrier, sensitivity
Size1.66 fl oz / 47 mL1.66 fl oz / 47 mL1.7 fl oz / 50 mL
Price$80$80$90
Pick it ifYour skin is truly dryYou're only a little dryYour skin is reactive

Where it fits in your evening routine

1Fooops! Wipesmakeup off23 in 1 Cleansercleanse3Facial Resurfacerexfoliate4Retinol Serumoptional5Evening Moisturizeryou are here

SeneGence’s evening order: remove makeup, 3 in 1 Cleanser, Facial Resurfacer, optional serums like the Advanced SenePlex+ Renewal Serum with Retinol, targeted care such as EyeCreme, then Evening Moisturizer to finish. In the morning, the Dry DayTime Moisturizer takes over.

What’s in it, in plain words

  • Orchid stem cells: SeneGence describes them as helping improve the appearance of sagging skin.
  • Niacinamide: a form of vitamin B3, a common skincare ingredient.
  • Hyaluronic acid (HA): a humectant that attracts and holds moisture.
  • SenePlex+: SeneGence’s proprietary complex, described as helping reduce signs of aging while moisturizing.

Sets that include this moisturizer

My tips

Tip 1

Don't wait long after your serums. Moisturizer on slightly damp skin feels more comfortable when you're dry.

Tip 2

Take it down your neck; it's one of the first places dryness shows and the easiest place to forget.

Tip 3

Starting the retinol serum? Begin a few nights a week under this moisturizer and build up as your skin allows.

❦

Evening Moisturizer (Dry) FAQs

What's the difference between the Dry DayTime and Evening Moisturizers?

The Evening formula uses orchid stem cells, niacinamide and HA and targets lines, dryness, texture and sagging. The DayTime formula uses Myrothamnus, copper tripeptide-1 and glycolic/lactic acid for dryness, lines and tone.

Can I use it with retinol?

SeneGence’s evening regimen places the Advanced SenePlex+ Renewal Serum with Retinol before Evening Moisturizer, so the moisturizer goes on top of it.

Is it good for sensitive skin?

It isn’t marketed specifically for sensitivity. For sensitive skin, SeneGence’s Microbiome Restorative Evening Moisturizer focuses on the barrier and sensitivity.

Is the Dry Evening Moisturizer worth $80?

If dryness and lines are your main concerns, it’s the step that stays on longest. The Dry SkinCare Regimen Set costs the same as buying its four pieces, but gets the whole routine in one order.

Shop the routine

Your night, for dry skin

Dry SkinCare Regimen Set by SeneGence

Sets & Collections

Dry SkinCare Regimen Set

$265 All four Dry steps

EyeCreme by SeneGence

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EyeCreme

$70 Eye step at night

Microbiome Restorative Evening Moisturizer by SeneGence

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Microbiome Restorative Evening Moisturizer

$90 For sensitive skin

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