The full review

SenePlex+ Retinol Serum review: my honest take

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*As stated by SeneGence.

This is SeneGence’s retinol serum, made for nights. It pairs encapsulated nano retinol with Nephoria, a rambutan-derived ingredient, and hyaluronic acid. The concerns listed are lines, texture and firmness. If you’ve been curious about retinol but want it inside the same routine as the rest of your SeneGence skincare, this is the one to look at.

Retinol rewards patience. Go slow, stay consistent, and wear SPF the next morning.

It belongs in the optional advanced anti-aging step of the evening routine, after cleansing and before treatments and your evening moisturizer. Retinol asks for a little patience: start a few nights a week and build up as your skin gets used to it. The catalog doesn’t list a retinol percentage, so go by how your skin feels rather than a number.

At $95 for 0.5 fl oz, it’s a small bottle, but a serum like this goes on in a thin layer. It’s Subscribe & Save eligible. If your skin doesn’t like retinol, or you want something for mornings too, the NeoTight Anti-Wrinkle Serum is the retinol-free route to lines and firmness.

Retinol Serum vs NeoTight vs SeneCell: which one for lines?

	SenePlex+ Retinol Serum My pick	NeoTight Anti-Wrinkle Serum	SeneCell StemCell Concentrate
Key ingredients	Encapsulated nano retinol, Nephoria, HA	Neodermyl, SYN-STAR tripeptide, Liftonin-Xpress	Orchid stem cells, Marimoist, cross-linked HA, ChroNOline
Retinol	Yes	No	No
When	Night	AM and PM treat step	Advanced step
Size / price	0.5 fl oz, $95	0.5 fl oz, $105	1.66 fl oz, $145
Pick it if	You want retinol for lines and texture	You want lines and firmness without retinol	Hydration and renewal matter most

Where it fits in your evening routine

1Fooops! Dual Phase Color Removerremove makeup23 in 1 Cleanser – Normal to Drycleanse3Retinol Serumyou are here4Evening Moisturizer – Normal to Dryseal it in

SeneGence lists the SenePlex+ Retinol Serum in the evening routine only, in the optional advanced anti-aging step. Remove makeup, cleanse, apply this, add any treatment, then your evening moisturizer. On retinol nights I’d skip the Facial Resurfacer so you’re not doubling up.

What’s in it, in plain words

• Encapsulated nano retinol: retinol wrapped in tiny capsules, the star of the formula and the reason it’s a night product.
• Nephoria (rambutan): an ingredient from rambutan fruit, listed alongside the retinol.
• Hyaluronic acid: a humectant that attracts and holds moisture.
• SenePlex+: SeneGence’s own complex, named in the product title, described as helping reduce signs of aging while moisturizing.

My tips

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SenePlex+ Retinol Serum FAQs

Can I use the SenePlex+ Retinol Serum in the morning?

SeneGence puts it in the evening routine only. Use it at night and wear a daytime SPF like Microbiome Defense SPF 15 the next morning.

What percentage of retinol is in it?

The catalog lists encapsulated nano retinol but doesn’t give a percentage. Start slowly and let your skin tell you how often to use it.

Is it good for beginners?

It can be, if you ease in. Use it a couple of nights a week at first, follow with moisturizer, and increase as your skin gets comfortable.

Can I use retinol while pregnant?

That’s a question for your doctor. Many people avoid retinol during pregnancy and nursing, so check before starting. The NeoTight Anti-Wrinkle Serum doesn’t list retinol.