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Digital Age Defense Serum by SeneGence

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Digital Age Defense Serum

An optional serum in SeneGence’s evening order, aimed at blue light, redness, fatigue and dryness.

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Core regimen (SenePlex+) · Skincare

Evening Moisturizer – Normal to Oily

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$80

Price on SeneGence, checked Sept 2026

Part of SeneGence’s Core regimen collection.

  • Made for normal to oily skin
  • Key ingredients: Orchid stem cells, HA, ReneSeed peptide
  • Targets lines, pores, firmness, tone

Size 1.66 fl oz · 47 mL

Details

Orchid stem cells, HA, ReneSeed peptide

What it addresses

Lines, pores, firmness, tone

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The full review

Evening Moisturizer (Normal to Oily) review: my honest take

ReviewCompareRoutineIngredientsSetsTipsFAQs

Skin typeNormal to oily

Key ingredientReneSeed peptide

Size1.66 fl oz / 47 mL

Price$80

The Normal to Oily Evening Moisturizer is the night finish of SeneGence’s core regimen for skin that gets shiny. It’s part of the SenePlex+ lineup and targets lines, pores, firmness and tone. It goes on last at night, after makeup removal, 3 in 1 Cleanser, Facial Resurfacer and any serums. Oily skin still needs a night moisturizer, and this is the one built for it.

Shiny skin still needs a night moisturizer. It just needs one made with pores in mind.

The formula uses orchid stem cells, which SeneGence says help improve the appearance of sagging skin, with hyaluronic acid and ReneSeed peptide. HA is a humectant that pulls in water, a good fit for oily skin that’s dehydrated rather than dry. It suits oily and combination skin that cares about pores and firmness. Reactive, breakout-prone skin is better served by the Microbiome line.

At $80 for 1.66 fl oz, it matches the other Evening formulas. The Normal-Oily SkinCare Regimen Set ($265) bundles it with the matching cleanser, DayTime Moisturizer and EyeCreme. If your oily skin is also sensitive, the Microbiome Restorative Evening Moisturizer ($90) is made for sensitive to oily skin, and it has a $75 refill pod.

Best for

Oily and combination skin that wants night moisture with a focus on pores, lines and firmness.

Skip it if

Your oily skin is sensitive or breakout-prone. The Microbiome Restorative Evening Moisturizer fits better.

Normal to Oily vs Microbiome Restorative vs Normal to Dry: which night moisturizer should you get?

Evening Moisturizer, Normal to Oily My pickMicrobiome Restorative Evening MoisturizerEvening Moisturizer, Normal to Dry
Skin typeNormal to oilySensitive to oilyNormal to dry
Key ingredientsOrchid stem cells, HA, ReneSeed peptideLactobacillus ferments, HA, DS-CERIX5 lipidsOrchid stem cells, mushroom stem, rosehip, mangosteen
TargetsLines, pores, firmness, toneLines, barrier, sensitivityLines, firmness, tone, dryness
Size1.66 fl oz / 47 mL1.7 fl oz / 50 mL1.66 fl oz / 47 mL
Price$80$90 ($75 refill)$80
Pick it ifYou're oily but not reactiveYour oily skin is sensitiveYou lean dry, not shiny

Where it fits in your evening routine

1Fooops! Wipesmakeup off23 in 1 Cleansercleanse3Facial Resurfacerexfoliate4Digital Age Defenseoptional serum5Evening Moisturizeryou are here

SeneGence’s evening order: remove makeup, 3 in 1 Cleanser, Facial Resurfacer, optional serums such as Digital Age Defense or the retinol serum, targeted care, then Evening Moisturizer. In the morning, switch to the Normal to Oily DayTime Moisturizer, which SeneGence describes as mattifying.

What’s in it, in plain words

  • Orchid stem cells: SeneGence describes them as helping improve the appearance of sagging skin.
  • Hyaluronic acid (HA): a humectant that attracts and holds moisture.
  • ReneSeed peptide: a peptide. SeneGence describes peptides as supporting skin and collagen production.
  • SenePlex+: SeneGence’s proprietary complex, described as helping reduce signs of aging while moisturizing.

Sets that include this moisturizer

My tips

Tip 1

Use a thinner layer on the T-zone and a normal one on your cheeks and neck.

Tip 2

Oily skin can still be dehydrated. If you feel tight after cleansing, don't skip this step to avoid oil.

Tip 3

Give it a few minutes to sink in before bed so more of it stays on your face than on your pillowcase.

❦

Evening Moisturizer (Normal to Oily) FAQs

Is the Evening Moisturizer good for oily skin?

The Normal to Oily version is made for it, with a focus on lines, pores, firmness and tone. It uses orchid stem cells, hyaluronic acid and ReneSeed peptide.

Normal to Oily Evening or Microbiome Restorative Evening Moisturizer?

Both suit oily skin. Pick the Microbiome Restorative ($90) if your skin is sensitive or its barrier feels stressed. Pick this one ($80) if pores and firmness are the focus.

Can I use the retinol serum with it?

SeneGence’s evening regimen places the Advanced SenePlex+ Renewal Serum with Retinol before Evening Moisturizer, so the moisturizer goes on top of it.

What's in the Normal-Oily SkinCare Regimen Set?

The Normal to Oily 3 in 1 Cleanser, DayTime and Evening Moisturizers, plus EyeCreme, for $265. See the Normal-Oily SkinCare Regimen Set.

Shop the routine

Oily skin, after dark

Normal-Oily SkinCare Regimen Set by SeneGence

Sets & Collections

Normal-Oily SkinCare Regimen Set

$265 All four Normal-Oily steps

Advanced SenePlex+® Renewal Serum with Retinol by SeneGence

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Advanced SenePlex+® Renewal Serum with Retinol

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DayTime Moisturizer – Normal to Oily by SeneGence

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DayTime Moisturizer – Normal to Oily

$70 Mattifying morning partner

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